Recently in biomaterials:
- For highly repetitive biopolymers such as collagen and spider silk, DNA synthesis is extremely challenging using modern techniques. To address this problem, Tang and Chilkoti developed an algorithm to optimize synthesis of DNA sequences for highly repetitive proteins. They arrived at a codon scrambling method by applying a variation on the Traveling Salesman problem, in which the computer is asked to find an optimal route that only visits each target once. They demonstrated the efficacy of their method by optimizing the sequences for 19 challenging, repetitive-sequence proteins, including elastin, collagen, TALENs and spider silk. DNA sequences for these proteins were commercially ordered and successfully cloned. Their work is found here.